Science and Technology
The mechanism of action
The oxidative damage to membranes is detrimental and cannot be sufficiently controlled by antioxidants. The most susceptible membrane damage that puts cells at risk of death is in the mitochondrial membrane.
Retrotope’s drug platform, isotopically stabilized PUFAs, are unique in drug discovery. They are based on essential nutrient fats which have no pharmacological effect in the natural form. But, in the deuterated form, are sensitive and specific drugs with highly non-linear reduction of lipid peroxidation damage. Our compounds are expected to be active across various indications without any significant side effects.