Nov
10
1:30 PM13:30

Lipid Peroxidation-Resistant Polyunsaturated Fatty Acids (PUFA)

Founder and Chief Scientist Misha Shchepinov will present:

PUFAs are essential nutrients vital for biological, particularly mitochondrial and neuronal, membranes. Unlike any other type of oxidative stress-related damage, lipid peroxidation is a chain process which, once initiated, can damage thousands of PUFA residues before the reaction is terminated. The rate limiting step of the process is hydrogen abstraction at the bis-allylic (between double bonds) site. Antioxidants are inefficient for various reasons. A novel approach employs deuteration of PUFAs at the bis-allylic positions to stops lipid peroxidation by inhibiting the rate limiting step (hydrogen abstraction) due to the isotope effect. Numerous cell culture and animal studies, as well as Phase I in humans, support the role of LPO in neurological and other diseases, and offer a novel therapeutical intervention.

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Sep
15
5:00 PM17:00

Understanding Energy for a Cure Symposium

  • USF Sam and Martha Gibbons Alumni Center (map)
  • Google Calendar ICS

Retrotope will be a presenter at this Symposium.

"Join USF Ataxia Research Center leadership, Dr. Theresa Zesiewicz MD., FAAN, along with FARA Executive Director, Jennifer Farmer and President, Ronald Bartek for a special interactive symposium focused on advancing therapeutic approaches. The symposium will feature updates for ongoing clinical trials along with drug discovery efforts targeting the root cause of this genetic disease. Top researchers will share insights into emerging treatments for Friedreich’s Ataxia. A special panel of individuals living with FA will also share their experiences and perspectives."

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Jun
15
10:30 AM10:30

13th International Conference on Wearable and Implantable Body Sensor Networks (BSN 2016)

  • UCSF Mission Bay Conference Center (map)
  • Google Calendar ICS

Poster session presentation by Dr. Robert LeMoyne on "Wearable Body and Wireless Inertial Sensors for Machine Learning Classification of Gait for People with Friedreich’s Ataxia"

Authors: Robert LeMoyne, Frederic Heerinckx, Tanya Aranca, Robert De Jager, Theresa Zesiewicz, Harry J. Saal

 

 

 

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Mar
25
to Mar 28

International Ataxia Research Conference 2015

Retrotope, Inc., an emerging, clinical stage degenerative disease therapeutic company, gave a presentation at the International Ataxia Research Conference.  The talk entitled: “An upcoming clinical trial testing the safety and efficacy of a stabilized polyunsaturated fatty acid in Friedreich’s ataxia” elucidated the company’s progress towards an Investigational New Drug (IND) application for the fatal, orphan disease, Friedreich’s ataxia (FRDA).   Currently, there is no approved therapy for FRDA. See the News section for further details.

 

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