Lipid Peroxidation-Resistant Polyunsaturated Fatty Acids (PUFA)

  • Chemistry and Biochemisty UCLA 3440 Molecular Sciences Building Los Angeles, CA 90095

Founder and Chief Scientist Misha Shchepinov will present:

PUFAs are essential nutrients vital for biological, particularly mitochondrial and neuronal, membranes. Unlike any other type of oxidative stress-related damage, lipid peroxidation is a chain process which, once initiated, can damage thousands of PUFA residues before the reaction is terminated. The rate limiting step of the process is hydrogen abstraction at the bis-allylic (between double bonds) site. Antioxidants are inefficient for various reasons. A novel approach employs deuteration of PUFAs at the bis-allylic positions to stops lipid peroxidation by inhibiting the rate limiting step (hydrogen abstraction) due to the isotope effect. Numerous cell culture and animal studies, as well as Phase I in humans, support the role of LPO in neurological and other diseases, and offer a novel therapeutical intervention.