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> January, 2014
Retrotope publishes its research on the mechanistic studies of the unusually high isotope effect in lipid peroxidation. See Lamberson et al, Unusual Kinetic Isotope Effects of Deuterium Reinforced Polyunsaturated Fatty Acids in Tocopherol Mediated Free Radical Chain Oxidations. Journal of the American Chemical Society, 2014, http://pubs.acs.org/doi/abs/10.1021/ja410569g
For more information please contact Retrotope at info@retrotope.com.

> January, 2014
Retrotope is to present at the Gordon Research Conference "Isotopes in Biological and Chemical Sciences" in Galveston, TX. http://www.grc.org/programs.aspx?year=2014&program=isotopes
For more information please contact Retrotope at info@retrotope.com.

 

> July, 2013
Retrotope publishes its research on the use of D-PUFA drugs to mitigate oxidative stress in Friedreich's ataxia models. See Cotticelli et al, Insights into the role of oxidative stress in the pathology of Friedreich Ataxia using peroxidation resistant polyunsaturated fatty acids. Redox Biology, 2013, http://www.sciencedirect.com/science/article/pii/S2213231713000529
For more information please contact Retrotope at info@retrotope.com.

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> March, 2013
Retrotope has been awarded a research grant from the HD foundation (http://hdfoundation.org/). For more information please contact Retrotope at info@retrotope.com.

 

> October, 2012
October, 2012:  Retrotope, Inc had an introductory (pre-IND) meeting with the FDA. At that meeting, FDA provided clear information and guidance on the requirements for Retrotope’s Investigational New Drug (IND) Application for a Phase Ib trial of Retrotope’s first drug in the orphan indication, Friedreich ataxia. Retrotope hopes to start this trial in 2013.  For more information please contact Retrotope atinfo@retrotope.com. 

 

> June 2012 
 Retrotope publishes its research on the "20% effect", whereby small amounts of PUFAs with deuterium atoms at the bis-allylic positions efficiently inhibit the chain reaction of PUFA peroxidation. See Hill et al,  Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Free Radical Biology and Medicine, 2012,  http://www.sciencedirect.com/science/article/pii/S0891584912003395?v=s5
For more information please contact Retrotope at info@retrotope.com



> April, 2012
Retrotope and SRI International will continue collaborating on Parkinson's disease. The National Institute of Aging (Drug Discovery mechanism) will fund the 2 year project "Isotopic Reinforcement to Minimize Nigrostriatal Degeneration". For more information please contact Retrotope at info@retrotope.com.



> December 2011

 Retrotope publishes its research on mitigation of symptoms ith the mouse model of Parkinson's disease. See Shchepinov et al,  Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson’s disease  Toxicology Letters 207 (2011) 97– 103. For more information please contact Retrotope at info@retrotope.com

 

> January, 2011
Retrotope publishes its research on reducing PUFA peroxidation in yeast models. See Hill S. et al, Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress. Free Radical Biology and Medicine, 2011;50:130-138, for more detail.
Retrotope publishes its research on inhibition of LOX. See Pestov N.B. et al, Control of lysyl oxidase activity through site-specific deuteration of lysine. Bioorganic and Medicinal Chemistry Letters 2011;21:255-258. See more detail here


> December, 2010
Retrotope has been awarded a research grant from the ALS Therapy Alliance (http://alstherapyalliance.org/). For more information please contact Retrotope at info@retrotope.com.


> October, 2010

Retrotope technology has been featured in the New Scientist magazine.
New Scientist, a weekly science and technology news magazine, has covered the Retrotope technology in its 29 October, 2010 issue (#2784). The feature, "Heavy hydrogen keeps yeast looking good" by Helen Thomson, can be found at:
http://www.newscientist.com/article/mg20827844.000-heavy-hydrogen-keeps-yeast-looking-good.html

> April, 2009
Retrotope has been awarded a Rapid Response Innovation Award from the MJFox Foundation for its project: “Isotopic Stabilization of Dietary Polyunsaturated Fatty Acids as a New Treatment Paradigm for Parkinson’s Disease: MPTP and Paraquat Mouse Model Feasibility Studies" http://www.michaeljfox.org/research_MJFFfundingPortfolio_searchableAwardedGrants_3.cfm?ID=557 For more information, please contact Retrotope at info@retrotope.com


> March, 2009

Chemistry & Industry, a biweekly chemical technology news magazine, has published a drug discovery feature story (Heavyweight Drugs, by Cath O'Driscoll, C&I 9 March 2009, p 24-26), covering approaches which employ the isotope effect to improve the pharmacokinetic properties of drugs and nutraceuticals, including the Retrotope technology. More information available here.

> January, 2009
Retrotope anti metastasis and LOX inhibition project has been awarded a 3 year grant from the Russian Academy of Sciences. For more information, please contact info@retrotope.com

> November, 2008. Retrotope technology has been featured in the New Scientist magazine.

New Scientist, a weekly science and technology news magazine, has published a feature story about Retrotope technology in its 29 November, 2008 issue (#2684). The feature, "Crunch time for ageing. Would eating heavy atoms lengthen our lives?" (by Graham Lawton), can be found at:
http://www.newscientist.com/article/mg20026841.800-would-eating-heavy-atoms-lengthen-our-lives.html?full=true

Some comments on that feature story can be found at:
http://www.newscientist.com/article/mg20126880.400-heavy-drinking-water.html and
http://www.newscientist.com/article/mg20126930.400-isotopes-and-ageing.html



Heavy isotopes to avert ageing?
by Vadim V. Demidov

Summary

Oxidative modifications of cellular components by free radicals are thought to be the cause of ageing and ageassociated diseases. Extensive prior research has aimed to lessen such damage by counteracting the free-radical oxidizers with antioxidants, but there have been no attempts to protect the oxidizer-targeted biomolecules by making them more stable against oxidation. A recent paper describes an original and promising method based on the use of non-radioactive heavy isotopes, which might enable living cells to resist the free-radical oxidation and consequently allow us to live a healthier, longer life.
Read more here: http://www.sciencedirect.com/science





 

 

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